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Skin disorders and psoriasis. The effect of fasting and calorie-restriction A fasting and vegetarian diet treatment trial on chronic inflammatory disorders. [Article in German] Asefi M, Augustin M Forsch Komplementarmed. 1999 Apr;6 Suppl 2:9-13. Universitats-Hautklinik Freiburg. Stimulation or regulation therapies are old therapeutic procedures based on models reaching back to traditional medical faculties in ancient times and in the Middle Ages. Among this heterogeneous group are acupuncture, purgative procedures (especially the Aschner methods), autohemotherapy, fasting therapy, homeopathy, microbiological and physical therapies. The basic principle underlying all of these procedures is that stimulants applied in proper doses to the organism elicit counterregulation. The counterregulation stimulates 'self-healing processes' within the organism. The efficacy of stimulation therapies was originally deduced mostly from traditional explanatory models which have lost their relevance for modern medicine. However, it has been found in applications in dermatology that many of these stimulation therapies can lead to clinical improvement in selected indications and that modern explanatory models can be found for these effects. This presentation reports on exemplary applications of stimulation therapies in dermatology. Traditional and modern concepts of action are compared. A fasting and vegetarian diet treatment trial on chronic inflammatory disorders. Indications for fasting Skin diseases Acta Derm Venereol 1983;63(5):397-403 Lithell H, Bruce A, Gustafsson IB, Hoglund NJ, Karlstrom B, Ljunghall K, Sjolin K, Venge P, Werner I, Vessby B. Twenty patients with arthritis and various skin diseases were studied on a metabolic ward during a 2-week period of modified fast followed by a 3-week period of vegetarian diet. During fasting, arthralgia was less intense in many subjects. In some types of skin diseases (pustulosis palmaris et plantaris and atopic eczema) an improvement could be demonstrated during the fast. During the vegan diet, both signs and symptoms returned in most patients, with the exception of some patients with psoriasis who experienced an improvement. The concentrations of lactoferrin in serum reflect the turnover and activity of neutrophil leukocytes. When this protein was initially increased it fell to normal values in most cases. The improvement or impairment of signs and symptoms was related to the lactoferrin levels in serum. Suppressive effects on allergic contact dermatitis by short-term fasting. Toxicol Pathol. 2001 Mar-Apr;29(2):200-7 Nakamura H, Kouda K, Fan W, Watanabe T, Takeuchi H. Department of Public Health, Hamamatsu University School of Medicine, Shizuoka, Japan. Fasting alters various hormonal and immune conditions. It has been reported that delayed type immune response to the injection of keyhole limpet hemocyanin was depressed by short-term fasting. In this study, we adopted the computer-assisted image analyzer for histopathological analysis and evaluated the influence of short-term fasting on allergic contact dermatitis induced by 2,4-dinitrofluorobenzene (DNFB). Mice were sensitized by painting of DNFB to the abdomen. After the sensitization, mice were challenged by DNFB painting to the ear. Fasting started 24 hour before (48-hour fasted group) or immediately after (24-hour fasted group) the challenging. Fasting without DNFB treatment did not induce remarkable change of ear thickness, ear tissue, serum albumin, serum total protein, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase. or serum creatine phosphokinase. In contrast, lasting suppressed the increment of ear thickness in the DNFB-treated group in this study. We could also demonstrate, using the computerized image analyzer, that both lymphocyte infiltration and the edema in the dermis were suppressed in fasted mice treated with DNFB. Further, edema in the dermis was inhibited more strongly in 48-hour fasted mice than in 24-hour lasted mice. These findings indicate that short-term fasting induce histopathological changes in the state of contact dermatitis. Fasting diet therapy for chronic urticaria: report of a case. J Dermatol. 1992 Jul;19(7):428-31 Okamoto O, Murakami I, Itami S, Takayasu S. Department of Dermatology, Oita Medical University, Japan. We used fasting diet therapy with a 28-year-old woman with chronic urticaria who responded only to systemic administration of glucocorticosteroids. The rashes began to decrease on the third therapeutic day and completely disappeared on the 11th day. Although the eruptions relapsed three days after the termination of the therapy, they were milder than previous ones. We also discussed the possible efficacy of fasting diet therapy for chronic urticaria as reported in the literature. A restricted-calorie diet inhibited the development of pre-cancerous growths in a mouse model of skin cancer. (Source: chinaview.cn April 14) Calorie restriction is reducing the activation of two signaling pathways known to contribute to cancer growth and development, a new study by U.S. researchers has shown. A restricted-calorie diet inhibited the development of pre-cancerous growths in a mouse model of skin cancer, reducing the activation of two signaling pathways known to contribute to cancer growth and development, a new study by U.S. researchers has shown. An obesity-inducing diet, by contrast, activated those pathways, a research team from the University of Texas' Anderson Cancer Center reported at the American Association for Cancer Research annual meeting Monday. "These results, while tested in a mouse model of skin cancer, are broadly applicable to epithelial cancers in other tissues," said the report's senior author John DiGiovanni. Cancers of the epithelium -- the tissue that lines the surfaces and cavities of the body's organs -- comprise 80 percent of all cancers. Calorie restriction and obesity directly affect activation of the cell surface receptors epidermal growth factor (EGFR) and insulin-like growth factor (IGF-1R). These receptors then affect signaling in downstream molecular pathways such as Akt and mTOR. Calorie restriction or negative energy balance inhibits this signaling, while obesity or positive energy balance enhances signaling through these pathways, leading to cell growth, proliferation and survival. Dietary energy balance refers to the relationship between caloric intake and energy expenditure. Previous research, both experimental and epidemiological, suggests that chronic positive energy balance, which can lead to obesity, increases the risk of developing a variety of cancers, while negative balance often decreases risk. "These new findings provide the basis for future translational studies targeting Akt/mTOR pathways through combinations of lifestyle and pharmacologic approaches to prevent and control obesity-related epithelial cancers in humans," DiGiovanni said. |
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